A single sample saliva test to determine acetylator phenotype
نویسندگان
چکیده
منابع مشابه
Plasma concentration and acetylator phenotype determine response to oral hydralazine.
The vasodepressor response to single and multiple oral doses of hydralazine, 1 mg/kg, was studied in hypertensive patients. The concentration of hydralazine in plasma was measured both by a newly developed specific and a nonspecific assay similar to those used in previous studies. Acetylator phenotype was determined following oral sulfamethazine. Plasma hydralazine concentration peaked at 1 hou...
متن کاملThe use of the autoanalyzer to determine the acetylator phenotype.
It has been pointed out (Rao et al, 1970) that with the advent of intermittent treatment regimens the determination of the acetylator phenotype has become of practical importance. It has recently been shown that rapid acetylators have an inferior response to slow acetylators when their tuberculosis is treated with once weekly treatment regimens (Menon, 1968; Tuberculosis Chemotherapy Centre, Ma...
متن کاملAcetylator phenotype in Iraqi patients with systemic lupus erythematosus.
The study was designed to determine the acetylator status in patients with systemic lupus erythematosus (SLE) and compare it to a matched group of healthy volunteers. Disease severity was determined using the revised American College of Rheumatology criteria for classification and the SLE disease activity index. After an overnight fast, each participant received a single oral dose of 100 mg dap...
متن کاملAcetylator phenotype in spontaneous SLE and rheumatoid arthritis.
Acetylator phenotype was determined in 22 patients with spontaneous systemic lupus erythematosus and the proportion of 'slow' acetylators compared with that obtained in a group of patients with rheumatoid arthritis and a group of healthy controls. 73% of the SLE group were designated 'slow' compared with 72% of the rheumatoid group and 64% of the control group. These differences were not signif...
متن کاملAcetylator phenotype and adverse effects of sulphasalazine in healthy subjects.
Sulphasalazine (salicyl-azo-sulphapyridine) was ingested by 27 healthy subjects for five days at a dosage of 4 g daily. The acetylator phenotype of each subject had been established previously. The serum concentrations of the parent drug and its sulphapyridine-metabolites were determined and the adverse effects were recorded. There was no correlation between the serum concentrations of sulphasa...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1996
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1996.tb00121.x